Trapped Neutrophil Syndrome

Body function:

Heart & Blood

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Trapped Neutrophil Syndrome (TNS) is an inherited autosomal recessive disease found in Border Collies. The condition is caused by a mutation in the Vesicle Protein Sorting 13B (VPS13B) gene, decreasing the production of white blood cells.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Border Collie

A white dog with a friendly expression is looking up at the camera with its mouth open and tongue out. The dog's fur is slightly ruffled.

What does this mean for a dog with this trait?

Unfortunately, there’s no cure for TNS, and most Border Collies will succumb to the illness. However, mild cases of TNS can be treated with medication and treatments that aim to improve a dog’s quality of life. Testing is essential to prevent the spread of this genetic condition.

Symptoms

TNS compromises a dog’s immune system, preventing it from fighting infections. It can also cause developmental issues and abnormalities, such as an elongated skull. Symptoms generally manifest between the ages of six weeks and 2 years.

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