Thrombopathia (Cavalier King Charles Spaniel)

Body function:

Heart & Blood

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Thrombopathia is a genetic disorder affecting Cavalier King Charles Spaniels, caused by a mutation in the RASGRP2 gene. This condition causes platelets to be unable to aggregate, preventing blood from clotting. The condition is inherited in an autosomal recessive manner, meaning both parents must carry the gene for a dog to be affected.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Cavalier King Charles Spaniel

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What does this mean for a dog with this trait?

There is no cure for thrombopathia. Veterinarians should be informed before any surgery so that they may have extra blood on hand in case a transfusion is needed. Dogs may also need more careful monitoring, especially for signs of internal bleeding like dark, bloody stool.

Symptoms

Dogs with thrombopathia may experience excessive bleeding from even minor injuries. They may also bruise easily and excessively. In some cases, thrombopathia may lead to deadly levels of blood loss.

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