Glanzmann Thrombasthenia Type I

Body function:

Heart & Blood

In collaboration with

Glanzmann Thrombasthenia Type 1 (GT) is an inherited bleeding disorder first identified in Pyrenean Mountain Dogs (Great Pyrenees). It's caused by a mutation in the ITGA2B gene, which leads to a deficiency or dysfunction of the platelet membrane glycoprotein αIIb β3 (also known as the fibrinogen receptor). This autosomal recessive condition results in impaired platelet aggregation and clot formation, leading to excessive bleeding tendencies. The disorder affects the dog's ability to form stable blood clots, making them prone to prolonged bleeding episodes.

In collaboration with

List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Great Pyrenees

A white dog with a friendly expression is looking up at the camera with its mouth open and tongue out. The dog's fur is slightly ruffled.

What does this mean for a dog with this trait?

While there is no cure for GT, management focuses on supportive care and preventing bleeding episodes. Iron supplementation is often necessary to prevent deficiency, especially during growth or periods of chronic bleeding. Owners should avoid medications that affect blood clotting and inform vets about the condition before procedures. With proper management, affected dogs can have a good prognosis and a relatively normal lifespan. However, they require vigilant care and preparedness for potential bleeding emergencies.

Symptoms

Dogs affected by GT typically show signs between 3 and 6 months of age. They often experience recurrent nosebleeds, which may continue until about 2 years of age. They are prone to easy bruising and may have prolonged bleeding after minor injuries. Surgical procedures or trauma can cause excessive bleeding that is difficult to control. Female dogs may experience prolonged bleeding during heat cycles. Affected dogs are also often smaller than the average for their breed.

200+ health condition screenings and counting

Like humans, the science surrounding canines is constantly evolving. The more we learn, the more we are able to make educated decisions when it comes to providing their care they deserve.

Explore conditions

Get even deeper insights with our
Breeds & Health kit

With tests for hundreds of breeds, behavioral traits, and health conditions, understanding your best friend has never been easier.

Note: A genetic test is not a diagnosis for disease. Consult any concerns with your vet.

Buy a kit