Thrombasthenia

Body function:

Heart & Blood

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Thrombasthenia is a genetic disorder affecting Otterhound dogs caused by a mutation in the ITGA2B gene. It prevents platelets in a dog’s blood from aggregating to form a blood clot, leading to excessive bleeding. This condition is inherited in the autosomal recessive fashion, meaning both parents must be carriers for offspring to be affected.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Otterhound

A white dog with a friendly expression is looking up at the camera with its mouth open and tongue out. The dog's fur is slightly ruffled.

What does this mean for a dog with this trait?

There is no known treatment for thrombasthenia. It’s vital to inform veterinarians before any surgery or procedure so they may have extra blood on hand in an emergency.

Symptoms

Signs of thrombasthenia include excessive bleeding from minor traumas. Signs most commonly appear during teething, causing dogs to bleed excessively as teeth come in. Dogs with the condition may also experience sudden nose bleeds and frequent bruising.

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