X-Linked Severe Combined Immunodeficiency

Body function:

Immune & Autoimmune

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X-linked severe combined immunodeficiency occurs in Basset Hounds due to a mutation on the IL2RG gene. Dogs with the disorder lack an important protein that supports immune function. As a result, they experience illness, chronic infections, and failure to thrive. The disorder often leads to death by 4 months of age.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Basset Hound

A brown dog with floppy ears is looking up at the camera with its mouth open and tongue out. The dog is standing in a field of tall grass.

What does this mean for a dog with this trait?

There is no known cure for X-linked severe combined immune-deficiency. Treatment includes addressing infections and other ailments with proper medication and care. Many find that euthanasia is the most compassionate choice for these dogs.

Symptoms

Basset Hounds with X-linked severe combined immune-deficiency begin to show signs around 2 months of age. They suffer from chronic infections, gastrointestinal distress, lethargy, and weight loss. These dogs typically die by 4 months of age.

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