Autosomal Recessive Severe Combined Immunodeficiency (Frisian Water Dog)

Body function:

Immune & Autoimmune

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Autosomal Recessive Severe Combined Immunodeficiency is an immunocompromising disease that inhibits the immune system’s production of white blood cells. Dogs with ARSCID are unable to fight infection and disease, resulting in early death. In Frisian Water Dogs, this is caused by a mutation in the RAG1 gene. Both parents must be carriers for ARSCID for the litter to be affected.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Frisian Water Dog

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What does this mean for a dog with this trait?

There is no cure for ARSCID. Treatment includes management of infections caused by the mutation and management of its symptoms. Dogs with symptoms of ARSCID should be seen by a veterinarian as soon as possible.

Symptoms

Frisian Water Dogs with ARSCID experience chronic infections and disease. They also may have digestive issues like chronic diarrhea and vomiting, weight loss, lethargy, retarded growth, and failure to thrive. These symptoms typically begin around 3 months of age. ARSCID almost always results in early death.

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