Rod-cone dysplasia 3

Body function:

Eyes

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Retinal atrophy, rod-cone dysplasia 3, is a progressive eye disease caused by a mutation of the PDE6A gene. It leads to the degeneration of the retina, beginning with the rods, which are responsible for night vision, and progressing to cones, which are responsible for day vision. Ultimately, the disease results in blindness.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Cardigan Welsh Corgi, Chinese Crested, Pomeranian

A brown and white dog with floppy ears is looking up at the camera with a big smile and its tongue hanging out.

What does this mean for a dog with this trait?

There is no known cure for rod-cone dysplasia 3. To care for dogs with this condition, provide extra light at night, remove or block access to potential hazards, and leash in unfamiliar situations.

Symptoms

Symptoms of rod-cone dysplasia 3 typically appear at about a month of age. Dogs will show signs of increasingly poor night vision. By 4 months of age, a retinal exam will show an abnormally reflective tapetum, the structure behind the retina. Over time, day vision will begin to deteriorate, too. By 4 years of age, dogs with rod-cone dysplasia 3 will experience total blindness.

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