Progressive Retinal Atrophy 1

Body function:

Eyes

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Progressive retinal atrophy 1 (PRA1) is a degenerative eye disease affecting Golden Retriever dogs that ultimately results in total blindness. It is caused by a mutation in the SLC4A3 gene and leads to retinal degeneration. For a litter to be affected, both parents must be carriers of PRA1.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Golden Retriever

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What does this mean for a dog with this trait?

Care for a dog with PRA1 includes minimizing hazards, keeping on a leash in unfamiliar environments, and increasing supervision. There is no cure for PRA1.

Symptoms

Signs of PRA1 appear around 6 years old. Dogs with the condition begin to show signs of worsening eyesight, like increased clumsiness, more apprehensive movement, and trouble tracking objects. Eventually, PRA1 leads to complete blindness.

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