X-Linked Progressive Retinal Atrophy Type 1

Body function:

Eyes

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X-linked progressive retinal atrophy type 1 is a degenerative eye disease that affects Samoyed and Siberian Husky dogs. It occurs due to a mutation in the RPGR gene. The condition causes degeneration of the rods and cones in a dog’s retina. Because this is an X-linked condition, female dogs must inherit two copies of the disease to be affected, while male dogs only need to inherit one.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Samoyed, Siberian Husky

A brown and white dog with floppy ears is looking up at the camera with a big smile and its tongue hanging out.

What does this mean for a dog with this trait?

There is no cure for X-linked progressive retinal atrophy type 1. As night blindness develops, dogs may be helped with additional lighting at night. Once dogs have lost all eyesight, they may require additional supervision and leashing in unfamiliar areas.

Symptoms

Signs of X-linked progressive retinal atrophy type 1 typically appear within the first 2 years of life. Dogs first show signs of night blindness, like increased clumsiness in low-light conditions. As the disease progresses, signs of blindness will occur during the day, too. Eventually, dogs will lose their eyesight altogether.

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