Cone-Rod Dystrophy 1

Body function:

Eyes

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CRD1 causes early-onset retinal degeneration in American Staffordshire Terriers. Those with two copies of the mutated gene will experience severe visual impairment in early adulthood. The condition is autosomal recessive, meaning both parents must be carriers for the offspring to be affected. Dogs with one normal and one CRD1 gene are carriers but don't show symptoms.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

American Staffordshire Terrier

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What does this mean for a dog with this trait?

Currently, there is no cure for CRD1. Treatment focuses on managing the condition and providing supportive care. Genetic testing can help identify carriers and prevent the condition in future generations.

Symptoms

Cone-Rod Dystrophy (CRD1) in American Staffordshire Terriers causes progressive retinal degeneration, leading to early-onset blindness. Symptoms typically become noticeable before the dog reaches one year of age. Initially, dogs with CRD1 may show subtle signs of visual impairment. As the condition progresses, these signs become more apparent.

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