Pyruvate Kinase Deficiency (Labrador)

Body function:

Heart & Blood

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Pyruvate Kinase Deficiency (PKD) in Labrador Retrievers is a genetic metabolic disorder caused by a PKLR gene mutation. PKD results in insufficient activity of the pyruvate kinase enzyme. This deficiency affects red blood cells, making them easily damaged, leading to hemolytic anemia.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Labrador Retriever

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What does this mean for a dog with this trait?

There is no cure for PKD in Labrador Retreievers. Vets will often recommend supervision and supportive care focused on quality of life. Unfortunately, pet parents should be prepared for a shortened lifespan.

Symptoms

Labrador Retrievers with PKD will experience symptoms between 4 months and 2 years of age. The first signs include pale gums, lethargy, and exercise intolerance. Dogs may also have enlarged livers and spleens. The severity of symptoms varies between dogs, but the condition is progressive. Affected dogs may experience episodes of severe anemia, which can be life-threatening. Unfortunately, most affected Labradors succumb to the disease by the age of 5.

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