Pyruvate Kinase Deficiency (Beagle)

Body function:

Heart & Blood

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Pyruvate Kinase Deficiency in Beagles is an inherited metabolic disorder caused by a mutation in the PKLR gene. To develop the condition, a dog must inherit one copy from each parent. PKD leads to insufficient activity in the pyruvate kinase enzyme, which is crucial for energy production in red blood cells. This deficiency causes premature destruction of red blood cells, leading to anemia and other complications.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Beagle

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What does this mean for a dog with this trait?

Beagles with PKD require close veterinary supervision and supportive care. Regular vet checkups monitor anemia levels, organ function, and more. There is no cure for PKD. Instead, care focuses on managing quality of life.

Symptoms

Symptoms of PKD in Beagles usually appear between 4 months and 2 years of age. The primary signs are pale gums due to anemia, lethargy, and exercise intolerance. As the disease progresses, dogs may become weak, have an increased heart rate, and experience weight loss. Dogs with PKD often have broken bones and enlarged spleen and liver. Some dogs may develop secondary conditions. While affected Beagles can live for several years with proper management, they typically pass away by around 9 years of age.

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