Prekallikrein Deficiency

Body function:

Heart & Blood

In collaboration with

Prekallikrein Deficiency, also known as Fletcher factor deficiency or Fletcher trait, is a rare inherited blood disorder affecting Shih Tzus. It results from a mutation in the KLKB1 gene and must be inherited from both parents. Prekallikrein is a protein crucial in blood clotting, and its deficiency can cause excessive bleeding when blood does not clot. While many affected dogs may not show obvious symptoms, the condition can potentially cause severe bleeding complications, especially during surgery or trauma.

In collaboration with

List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Shih Tzu

A white dog with a friendly expression is looking up at the camera with its mouth open and tongue out. The dog's fur is slightly ruffled.

What does this mean for a dog with this trait?

Caring for dogs with Prekallikrein Deficiency primarily involves preventative measures and careful management during medical procedures. Regular checkups can monitor your dog's health and clotting times. Veterinarians must be informed about the dog's condition before any surgical procedures, as they may need to take extra precautions. Dogs should also avoid taking medications that can affect blood clotting without veterinary guidance.

Symptoms

Prekallikrein Deficiency symptoms can be subtle and may not be apparent until the dog experiences trauma or undergoes surgery. Affected dogs have increased blood clotting times, which can lead to various symptoms. These may include easy bruising, frequent nosebleeds, and prolonged bleeding after injury or surgical procedures.

200+ health condition screenings and counting

Like humans, the science surrounding canines is constantly evolving. The more we learn, the more we are able to make educated decisions when it comes to providing their care they deserve.

Explore conditions

Get even deeper insights with our
Breeds & Health kit

With tests for hundreds of breeds, behavioral traits, and health conditions, understanding your best friend has never been easier.

Note: A genetic test is not a diagnosis for disease. Consult any concerns with your vet.

Buy a kit