Osteosarcoma (Leonberger)

Body function:

Skeletal & Joint

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Osteosarcoma in Leonberger dogs is a genetic form of bone cancer that is associated with mutations in the CDKN2A and CDKN2B genes, though its exact cause is unknown. This form of cancer most commonly affects long bones, like leg bones. It is a particularly aggressive cancer and metastasizes quickly.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Leonberger

A brown dog is sitting on its hind legs with its front paw raised. The dog is looking up at the camera with a hopeful expression.

What does this mean for a dog with this trait?

Osteosarcoma cannot be cured, but surgical amputation may stop the spread of the tumor if caught early enough. Otherwise, chemotherapy may extend life between 6 months and 1 year. Medications may also be prescribed to manage pain.

Symptoms

Early signs of osteosarcoma include lameness and reluctance to use a specific limb, plus a noticeable mass on the limb. Over time, dogs lose their appetite and experience weight loss. As the cancer metastasizes to the lungs, breathing may become difficult.

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