Alport Syndrome (English Cocker Spaniel)

Body function:

Skeletal & Joint

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Alport syndrome is a hereditary condition caused by a mutation in the COL4A4 gene that responsible for the structural integrity of type IV collagen in the kidneys. It leads to progressive renal failure and is identified in breeds such as Samoyeds, English Cocker Spaniels, Bull Terriers, and Dalmatians. There are three types of Alport syndrome: X-linked (XLAS), autosomal recessive (ARAS), and autosomal dominant (ADAS), with each type impacting specific breeds.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

English Cocker Spaniel

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What does this mean for a dog with this trait?

Managing Alport syndrome focuses on supportive care to slow the progression of kidney disease. Regular vet check-ups can help monitor kidney function, and treatments may include a diet low in protein and phosphorous to reduce the strain on the kidneys. Medications like ACE inhibitors can help manage some symptoms. In advanced cases, dogs may require dialysis or kidney transplantation, although these options are rare. Breeds prone to Alport syndrome, such as Samoyeds and Bull Terriers, should undergo genetic testing to identify carriers and prevent the spread of the condition.

Symptoms

Alport syndrome primarily manifests as kidney-related issues, leading to chronic renal failure. Common symptoms include excess proteins in the urine, which progresses to more severe kidney dysfunction as the disease advances. Affected dogs may experience lethargy, weight loss, vomiting, and increased thirst and urination.

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