Canine Multifocal Retinopathy 1

Body function:

Eyes

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Canine multifocal retinopathy 1 is an eye disease caused by a mutation of the Bestrophin 1 gene. It typically appears between 3 and 4 months of age and causes the retina to detach, allowing fluid to accumulate beneath the detached retina. This mutation is inherited in the autosomal recessive fashion, meaning both parents must be carriers of the disease for a puppy to be affected. The disease usually stops progressing around 1 year of age.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Boerboel, Mastiff, Great Pyrenees

A brown and white dog with floppy ears is looking up at the camera with a big smile and its tongue hanging out.

What does this mean for a dog with this trait?

Canine multifocal retinopathy 1 may lead to vision loss and retinal degeneration. There is no known treatment for the disease. Dogs with these symptoms may need additional lighting, especially at night, and more supervision.

Symptoms

Dogs with canine multifocal retinopathy 1 develop gray, tan, orange, or pink spots that appear as blisters in the back of the eye. In some cases, these blisters can heal. In others, they can lead to vision impairment and retinal degeneration.

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