Mucopolysaccharidosis Type 3A

Body function:

Muscle & Neurological

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Mucopolysaccharidosis type 3A (MPS IIIA) is a hereditary lysosomal storage disorder found in Dachshunds. It is caused by a deletion mutation in the SGSH gene. This mutation leads to a deficiency in the enzyme heparan N-sulfatase, which is crucial for breaking down heparan sulfate. When the enzyme is insufficient, heparan sulfate accumulates in cells. The buildup can affect the nervous system, resulting in progressive neurological symptoms.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Dachshund

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What does this mean for a dog with this trait?

While there is no cure for MPS IIIA, supportive care can help manage symptoms. Frequent vet check-ups can track the progress of neurological symptoms. Providing ramps or supportive devices to help the dog navigate stairs and other obstacles can also be helpful. Vets may also prescribe medications to alleviate discomfort or pain associated with the disease.

Symptoms

Dogs affected by MPS IIIA typically begin showing signs around three years of age. Common symptoms include uncoordinated movements and frequent stumbling, head tremors, a swaying gait, loss of reflexes, and abnormal eye movements.

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