Metabolizer of a Cognitive Enhancer

Body function:

Metabolic & Digestive

In collaboration with

Different variations in the CYP1A2 gene affect how dogs metabolize certain drugs like cognitive enhancers. Dogs with these variations have differing abilities to break down the medications. In dogs who metabolize these drugs poorly, drugs stay in their system longer, affecting both the efficacy and safety of the medications.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Beagle

A brown and white dog is running through a grassy field. The dog's tail is wagging, and it looks happy and energetic. There are some rocks and trees in the background.

What does this mean for a dog with this trait?

In dogs with variations in the CYP1A2 gene, medication dosage may need to be adjusted or alternative medications may be used. Veterinarians should also be informed before administering any drugs so that they may monitor for signs of overdose or dangerous prolonged side effects.

Symptoms

In dogs with a poor ability to metabolize these medications, the efficacy of the drugs may be diminished. They also may experience side effects like prolonged sedation or overstimulation.

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