Leukocyte Adhesion Deficiency Type III

Body function:

Heart & Blood

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Leukocyte adhesion deficiency type III is a genetic disorder affecting Irish Setter and German Shepherd dogs caused by a mutation in the FERMT3 gene. The blood disorder causes abnormal blood clotting and issues with the immune system.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

German Shepherd

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What does this mean for a dog with this trait?

There is no known cure for leukocyte adhesion deficiency type III. Veterinarians should be informed before surgery so they may have extra blood on hand in case of transfusion.

Symptoms

Dogs with leukocyte adhesion deficiency type III experience symptoms like recurring skin infections, boils, ulcers, gingivitis, and even bone infections. Dogs can also experience severe bleeding from trauma or surgery. Cases can range in severity from total life expectancy to early death.

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