Canine Leukocyte Adhesion Deficiency

Body function:

Immune & Autoimmune

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Canine leukocyte adhesion deficiency (CLAD) is a blood disorder resulting from a mutation in the ITGB2 gene. It affects both blood cell and platelet activity, leading to abnormal blood clotting and poor immune system functioning. This mutation specifically affects Irish Setters and German Shepherd Dogs. Both parents must be carriers of the CLAD mutation for a puppy to be affected.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Irish Setter, Irish Red And White Setter

A brown dog with floppy ears is looking up at the camera with its mouth open and tongue out. The dog is standing in a field of tall grass.

What does this mean for a dog with this trait?

While there is no known cure for CLAD, resulting infections can be treated with antibiotics and antifungal medications. Immunoglobulin therapy may also help manage infections. Notify your veterinarian of the condition before any surgical procedure.

Symptoms

CLAD can lead to chronic skin infections, bone infections, and chronically unhealed wounds among both German Shepherd Dogs and Irish Setters. Irish Setters may also suffer from umbilical vein infection and swollen lymph nodes. Though the condition itself is not deadly, dogs with the mutation may die from severe infection or bleeding that cannot clot.

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