Imerslund-Grasbeck Syndrome

Body function:

Metabolic & Digestive

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Imerslund-Grasbeck syndrome is a genetic disease that affects Beagles and Border Collies and is caused by a mutation in the CUBN gene. Dogs with the condition are unable to absorb vitamin B12. This condition is inherited in the autosomal recessive fashion, meaning both parents must be carriers for a litter to be affected.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Border Collie

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What does this mean for a dog with this trait?

Imerslund-Grasbeck syndrome can be easily managed with a regular B12 supplement.

Symptoms

Dogs with Imerslund-Grasbeck syndrome can suffer from lethargy, malaise, lack of appetite, and more. They may also suffer from anemia as a result of the disease. If left untreated, Imerslund-Grasbeck syndrome can cause permanent brain damage and nervous system damage.

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