Intestinal Cobalamin (Vitamin B12) Malabsorption (Komondor)

Body function:

Metabolic & Digestive

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Intestinal cobalamin malabsorption, also known as Imerslund-Gräsbeck syndrome, is a genetic disorder in Komondor dogs due to a mutation in the CUBN gene. The condition affects the small intestine’s absorption of cobalamin, also known as Vitamin B12.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Komondor

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What does this mean for a dog with this trait?

Intestinal cobalamin malabsorption can be treated with a vitamin B12 supplement, which must be taken for life.

Symptoms

Signs of intestinal cobalamin malabsorption typically appear in the first 3 months of life. Dogs become extremely weak and growth is slow. They may experience vomiting, diarrhea, and decreased white blood cell count. They also can suffer from liver disease and anemia.

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