Congenital Hypothyroidism (Spanish Water Dog)

Body function:
Reproductive & Urinary
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Congenital hypothyroidism is a genetic disorder affecting thyroid function in Spanish Water Dogs. This condition results in insufficient production of thyroid hormones crucial for growth and metabolism. The disease manifests early in life and is caused by a mutation in the thyroid peroxidase (TPO) gene, which impairs the thyroid gland’s ability to synthesize hormones effectively.
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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Spanish Water Dog

A black dog with a tan chest and a red and black collar is sitting in the grass. The dog's head is turned to the side, and it is looking up. There are trees in the background.

What does this mean for a dog with this trait?

Congenital hypothyroidism in Spanish Water Dogs is a lifelong condition requiring careful management. The primary approach involves early diagnosis and monitoring to address the symptoms as they arise. Affected dogs should be observed closely for signs of growth retardation, delayed developmental milestones, and worsening of thyroid-related symptoms.

Symptoms

This disorder is characterized by the presence of goiter and various developmental abnormalities, severely impacting the affected dogs' overall health and development. Congenital hypothyroidism in Spanish Water Dogs typically becomes evident within the first week of life. Affected puppies often exhibit significant lethargy and failure to thrive, alongside a distinctive goiter, which is an enlarged thyroid gland. They may also display stunted growth, resulting in dwarfism and delayed developmental milestones such as teething and opening the eyes and ears. Additional symptoms include thickened subcutaneous tissue, abnormal hair growth, and delayed skeletal development, including vertebral and limb dysplasia. Without intervention, these puppies may experience severe complications and early death due to progressive thyroid dysfunction.

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