Hypomyelination

Body function:

Muscle & Neurological

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Hypomyelination is a genetic neurological disorder in Weimaraners characterized by tremors during puppyhood. It is caused by a mutation in the gene encoding folliculin-interacting protein 2 (FNIP2). The tremors occur due to impaired myelination in the spinal cord, affecting the nervous system's ability to relay messages effectively.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Weimaraner

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What does this mean for a dog with this trait?

There is no cure for hypomyelination, and treatment focuses on managing symptoms and providing supportive care. Most puppies will eventually recover.

Symptoms

Puppies with hypomyelination begin to show signs of tremors as early as two weeks old. These tremors are noticeable when the puppies are awake and typically diminish by the age of 3 to 4 months. While the majority of affected puppies recover from the tremors, some may continue to exhibit mild tremors in their hind legs.

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