Primary Hyperoxaluria

Body function:

Metabolic & Digestive

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Primary hyperoxaluria is a genetic disorder that affects Coton de Tulear dogs and is caused by a mutation in the AGXT gene. Dogs with primary hyperoxaluria lack the enzymes needed to break down glyoxylate, causing a build-up of both oxalate and calcium oxalate crystals in the kidneys. This disorder leads to death within the first few months of life.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Coton De Tulear

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What does this mean for a dog with this trait?

There is no known cure for primary hyperoxaluria. Many choose compassionate euthanasia by 2 months of age.

Symptoms

Dogs with primary hyperoxaluria show symptoms of renal failure around the first month of life. They may experience vomiting, lethargy, lack of appetite, bloody urine, and abdominal pain. The disorder most often leads to death by 2 months of age.

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