Factor IX Deficiency (Rhodesian Ridgeback)

Body function:

Heart & Blood

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Factor IX Deficiency, also known as Hemophilia B, is a rare blood disorder in Rhodesian Ridgebacks where the blood cannot clot properly, leading to excessive bleeding. This disorder is caused by the hereditary deficiency of the clotting protein Factor IX, with a missense mutation (c.731G>A) in exon 7 of the F9 gene. Male dogs are more affected because they only have one X chromosome, but females are still at risk if both X chromosomes carry the mutation. They can also be carriers.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Rhodesian Ridgeback

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What does this mean for a dog with this trait?

To care for a dog with this disorder, minimize the risk of trauma and injury by avoiding rough play and harmful environments. Maintain good dental hygiene to prevent gum bleeding. There is no cure; however, veterinarians can provide antifibrinolytic agents to stem the bleeding and, if necessary, transfusions of fresh blood.

Symptoms

Clinical signs of Hemophilia B include prolonged bleeding from injuries, trauma or surgeries, internal bleeding, episodes of lameness, bruising, weakness, lack of appetite, fever, depression, and anemia. Symptoms usually appear before the dog is six months old.

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