Factor VIII Deficiency (Great Dane)

Body function:

Heart & Blood

In collaboration with

Hemophilia A is a genetic blood clotting disorder caused by a mutation in the F8 gene on the X chromosome. Due to its X-linked recessive inheritance pattern, it primarily affects males. This condition was first identified in Boxers but can occur in other breeds. Hemophilia A results in impaired blood clotting, leading to excessive bleeding from injuries or even spontaneously.

In collaboration with

List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Great Dane

A white dog with a friendly expression is looking up at the camera with its mouth open and tongue out. The dog's fur is slightly ruffled.

What does this mean for a dog with this trait?

There is no cure for Hemophilia A in dogs. Care focuses on prevention, vigilant monitoring, and fast treatment of bleeding episodes. Owners should avoid activities that can cause injury and provide a safe environment to minimize trauma risks. A veterinarian should quickly address any signs of bleeding or bruising. While there is no cure, there has been progress in laboratory settings with protein replacement and gene therapy, offering hope for future generations.

Symptoms

Symptoms of Hemophilia A manifest in puppies or young adult dogs. Affected dogs may experience spontaneous bleeding in the chest, abdomen, or joints. They often develop bruising and profuse bleeding following trauma or surgery. Puppies might show abnormal bleeding while teething. Dogs with this condition may exhibit swollen joints, difficulty breathing, and a sagging abdomen due to internal bleeding.

200+ health condition screenings and counting

Like humans, the science surrounding canines is constantly evolving. The more we learn, the more we are able to make educated decisions when it comes to providing their care they deserve.

Explore conditions

Get even deeper insights with our
Breeds & Health kit

With tests for hundreds of breeds, behavioral traits, and health conditions, understanding your best friend has never been easier.

Note: A genetic test is not a diagnosis for disease. Consult any concerns with your vet.

Buy a kit