Factor VIII Deficiency (Boxer)

Body function:

Heart & Blood

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Factor VIII Deficiency is a genetic bleeding disorder with a Boxer breed variant. This condition results in a deficiency of coagulation factor VIII, a protein essential for normal blood clotting. The disease primarily affects male dogs, while females are carriers. This specific mutation (c.1412C>G in exon 10) was identified in Boxers in 2015.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Boxer

A white dog with a friendly expression is looking up at the camera with its mouth open and tongue out. The dog's fur is slightly ruffled.

What does this mean for a dog with this trait?

Hemophilia A has no cure, so care focuses on management and prevention. Owners should create a safe environment to minimize the risk of injury. Regular veterinary check-ups can help monitor the dog's condition. In surgery, blood products should be readily available for potential transfusions. While most affected dogs can lead normal lives with proper care, owners should be prepared for potential emergencies and work closely with their vet to develop a care plan.

Symptoms

Dogs affected by Hemophilia often bruise easily and have prolonged bleeding following injuries or surgical procedures. Affected puppies might bleed excessively when losing their baby teeth. Frequent nosebleeds are common, and dogs may show signs of stiffness or lameness due to joint and muscle bleeding. In some cases, internal bleeding can cause difficulty breathing or a swollen abdomen.

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