Factor VIII Deficiency (Old English Sheepdog)

Body function:
Heart & Blood
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Hemophilia A in Old English Sheepdogs is a bleeding disorder caused by a mutation in the F8 gene on the X chromosome. This X-linked recessive condition primarily affects male dogs, while females can be carriers. The disorder results in a severe deficiency of coagulation Factor VIII, leading to impaired blood clotting.
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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Old English Sheepdog

A white dog with a friendly expression is looking up at the camera with its mouth open and tongue out. The dog's fur is slightly ruffled.

What does this mean for a dog with this trait?

Management of the disorder focuses on prevention and supportive care. Pet parents should create a safe environment for their dogs and schedule regular veterinary check-ups to monitor the condition. In case of bleeding episodes, dogs may require blood transfusions to ensure proper clotting. Owners should be prepared for potential emergencies.

Symptoms

Old English Sheepdogs may exhibit various symptoms related to impaired blood clotting ability. These symptoms can include recurrent soft-tissue hemorrhage and hemarthrosis (bleeding into joints). Affected dogs may experience spontaneous internal bleeding, particularly in the abdomen, which can be life-threatening. They often develop hematomas without apparent injury. During the shedding of baby teeth, puppies may experience prolonged bleeding. Any trauma or surgical procedure can result in excessive and difficult-to-control bleeding.

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