Factor VIII Deficiency (German Shepherd)

Body function:
Heart & Blood
In collaboration withDutch logo
Hemophilia A in German Shepherds is an inherited bleeding disorder caused by mutations in the F8 gene, which can lead to a deficiency in coagulation factor VIII. Two independent mutations have been identified: c.98G>A (HEMA-1) and c.16434>A (HEMA-2). This X-linked recessive condition primarily affects male dogs, while females are more commonly carriers.
In collaboration with Dutch logo

List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

German Shepherd

A white dog with a friendly expression is looking up at the camera with its mouth open and tongue out. The dog's fur is slightly ruffled.

What does this mean for a dog with this trait?

There is no treatment for Hemophilia A. Instead, care focuses on management in the form of creating safe environments. Vets will focus on prevention and have blood products readily available for potential transfusions during surgical procedures. Dogs with unexplained bruising or prolonged bleeding should get veterinary attention right away.

Symptoms

Dogs with Hemophilia A often bruise easily and have bleeding episodes, such as nosebleeds and blood from the mouth. Signs of lameness or stiffness can also occur. In more dangerous cases, dogs may experience internal bleeding. The variability in symptom severity means some dogs might not be identified as affected until they undergo surgery or experience trauma, resulting in excessive bleeding.

200+ health condition screenings and counting

Like humans, the science surrounding canines is constantly evolving. The more we learn, the more we are able to make educated decisions when it comes to providing their care they deserve.

Explore conditions

Get even deeper insights with our
Breeds & Health kit

With tests for hundreds of breeds, behavioral traits, and health conditions, understanding your best friend has never been easier.

Note: A genetic test is not a diagnosis for disease. Consult any concerns with your vet.

Buy a kit