Glycogen Storage Disease Type IIIa

Body function:

Metabolic & Digestive

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Glycogen storage disease type IIIA is a genetic condition caused by a mutation of the AGL gene and most commonly affecting Curly Coated Retriever dogs. The condition makes a dog unable to break down glycogen, causing it to build up in vital organs like the heart, liver, and kidney.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Curly-coated Retriever

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What does this mean for a dog with this trait?

There is no known cure for glycogen storage disease type IIIA. Care includes managing symptoms and monitoring energy levels.

Symptoms

Symptoms of glycogen storage disease type IIIA typically appear just after the first year of age. They include lethargy, lower-than-average blood sugar, and general failure to thrive. These dogs may also suffer from exercise intolerance due to their low blood sugar. Over time, excess glycogen will lead to muscle and liver damage.

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