Glycogen Storage Disease Type II

Body function:

Metabolic & Digestive

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Glycogen storage disease type II, also known as Pompe’s disease, is an inherited disorder caused by a mutation of the GAA gene. It primarily affects Finnish and Swedish Lapphund dogs. Dogs with glycogen storage disease type II are unable to break down glycogen, leading to a buildup in the heart, liver, and kidneys. The condition is ultimately fatal to affected dogs.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Finnish Lapphund, Swedish Lapphund

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What does this mean for a dog with this trait?

There is no known treatment for glycogen storage disease type II. Care may be given to manage symptoms, but the disease will inevitably result in death.

Symptoms

Signs of glycogen storage disease type II typically appear around 6 months of age. They include weight loss, vomiting, and heart issues. Glycogen storage disease type II can also result in a dilated esophagus and enlarged heart. Dogs with this condition typically die by 1.5 years of age.

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