Glycogen Storage Disease Type Ia

Body function:

Metabolic & Digestive

In collaboration with

Glycogen storage disease type IA is an inherited disorder that affects a dog’s ability to break down glycogen, leading to a dangerous build up of glycogen in the liver, heart, and kidneys. This condition primarily affects Maltese dogs and is caused by a genetic mutation of the G6PC gene. Most dogs with this mutation die during gestation. Those who survive gestation rarely live past 6 months of age.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Maltese

A brown and white dog is running through a grassy field. The dog's tail is wagging, and it looks happy and energetic. There are some rocks and trees in the background.

What does this mean for a dog with this trait?

There is no known cure for glycogen storage disease type IA. Management of the symptoms may include IV dextrose to combat low blood sugar. However, this treatment is only temporary. Compassionate euthanasia is a common choice for dogs with the condition.

Symptoms

Glycogen storage disease type IA can lead to weight loss, lethargy, hypoglycemia, enlarged liver, and more. Dogs with the condition experience a general failure to thrive. Eventually, glycogen storage disease will lead to an early death.

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