Musladin-Lueke Syndrome

Body function:

Skeletal & Joint

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Musladin-Leuke syndrome is a genetic disease caused by a mutation of the ADAMTSL2 gene. It specifically affects Beagles and their development of connective tissue. It can also impact organs, bone, heart, skin, and muscle.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Beagle

A brown dog is sitting on its hind legs with its front paw raised. The dog is looking up at the camera with a hopeful expression.

What does this mean for a dog with this trait?

There is no known cure for Musladin-Leuke syndrome, though symptoms typically stabilize around 1 year of age. Dogs with this disorder can lead full, happy lives.

Symptoms

Symptoms include stiff joints, tip-toe walking, stunted growth, thick and tight skin, and facial deformities. Dogs with the condition may experience seizures and chronic pain. Musladin-Leuke syndrome also commonly leads to arthritis later in life.

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