GM2 Gangliosidosis (Small Poodle)

Body function:

Muscle & Neurological

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GM2 Gangliosidosis is a severe, inherited neurological condition that affects Toy Poodles. A mutation in the HEXB gene causes it. This disease is a lysosomal storage disorder, leading to the progressive destruction of brain and spinal cord nerve cells.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Toy Poodle

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What does this mean for a dog with this trait?

There is no cure for GM2 Gangliosidosis, and affected dogs require supportive care to manage symptoms. As the disease progresses, the quality of life diminishes, often leading to euthanasia for welfare reasons by the age of two years.

Symptoms

Toy Poodles with GM2 Gangliosidosis typically begin showing signs between 9 and 12 months of age. Initial symptoms may include tremors, a stiff or uncoordinated gait, and difficulty eating. As the disease worsens, neurological functions deteriorate quickly.

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