GM2 Gangliosidosis (Japanese Chin)

Body function:

Muscle & Neurological

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GM2 Gangliosidosis is a fatal neurodegenerative disorder found in Japanese Chin dogs, caused by a mutation in the HEXA gene. This condition results in progressive damage to the nervous system due to the accumulation of GM2 gangliosides, which the body can't properly break down.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Japanese Chin

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What does this mean for a dog with this trait?

There is no cure for GM2 Gangliosidosis, and care is primarily supportive. Pet parents should work closely with a vet to monitor the dog's condition and manage symptoms as they arise.

Symptoms

Affected dogs typically begin showing symptoms between 0 and 2 years of age. The most common symptoms include ataxia (uncoordinated movements) and intention tremors, which worsen over time. As the disease progresses, dogs may experience vision impairment, altered mental status, and difficulties with feeding and movement. Due to the severity of these symptoms, most affected dogs are euthanized by the age of two.

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