Gangliosidosis

Body function:

Metabolic & Digestive

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Gangliosidosis is a genetic disorder affecting Shiba Inus caused by a mutation in the b-galactosidase gene. It causes the accumulation of a lipid important for nerve cell function. This condition is inherited in the autosomal recessive fashion, meaning both parents must be carriers for a litter to be affected.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Portuguese Water Dog

A brown and white dog is running through a grassy field. The dog's tail is wagging, and it looks happy and energetic. There are some rocks and trees in the background.

What does this mean for a dog with this trait?

There is no known cure or treatment for gangliosidosis. Dogs with the condition are typically euthanized due to poor quality of life.

Symptoms

Symptoms of gangliosidosis typically appear within the first 6 months of age. They include loss of vision, loss of balance, and weight loss. Dogs may also experience head tremors. The disease progresses quickly, and most dogs die by 18 months of age.

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