Factor VII deficiency

Body function:

Heart & Blood

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Factor VII deficiency is a genetic disorder caused by a mutation in the F7 gene. Factor VII is an essential element in blood coagulation. Without proper levels, the body is unable to clot. This condition is inherited in an autosomal recessive pattern, meaning both parents must be carriers for offspring to be at risk of inheriting the disease.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

American Pit Bull Terrier, American Water Spaniel, Australian Shepherd, Bernese Mountain Dog, Border Collie, Borzoi, Boxer, Cavalier King Charles Spaniel, Chesapeake Bay Retriever, Czechoslovakian Vlcak, Collie, English Springer Spaniel, French Bulldog, German Shepherd, Great Pyrenees, Irish Setter, Pembroke Welsh Corgi, Rhodesian Ridgeback, Romanian Mioritic Shepherd Dog, Rottweiler, Saint Bernard, Shiloh Shepherd, Soft Coated Wheaten Terrier, Tibetan Terrier, Wire Fox Terrier

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What does this mean for a dog with this trait?

There is no known cure for factor VII deficiency. It’s imperative to inform your veterinarian before any potential surgeries. Additional supervision may also be required to avoid trauma during playtime.

Symptoms

Symptoms of factor VII deficiency typically appear after a significant trauma or surgery. It is especially common to discover the condition during a spay or neuter, as this is the first surgery most dogs experience. Dogs with the condition experience excessive bleeding and may risk deadly levels of blood loss.

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