Lagotto Storage Disease

Body function:

Muscle & Neurological

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Lagotto storage disease (LSD) in Lagotto Romangnolos is caused by a mutation in the ATG4D gene, leading to progressive neurological symptoms, including cerebellar ataxia, which affects the part of the brain responsible for coordinating voluntary movements.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Lagotto Romagnolo

A black and white dog with a happy expression is looking up at the camera with its mouth open. The dog's ears are perked up, and it appears to be excited.

What does this mean for a dog with this trait?

Managing LSD focuses on maintaining comfort and quality of life. While there's no cure, supportive care, including physical therapy and medications to manage symptoms, may help. Environmental modifications, such as providing non-slip surfaces and avoiding stairs, may prevent injuries.

Symptoms

LSD symptoms typically appear between 4 months and 4 years of age. Affected dogs exhibit cerebellar ataxia, characterized by unsteady movements, tremors, and abnormal eye movements. Behavior changes, such as restlessness, depression, and aggression, are also common.

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