Cystinuria (Newfoundland)

Body function:

Metabolic & Digestive

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Cystinuria is a kidney disorder that occurs in Newfoundland dogs due to a mutation in the SLC3A1 gene. The mutation causes high levels of cystine to build up in the urine, forming crystals and stones that block the urethra.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Newfoundland

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What does this mean for a dog with this trait?

The first line of defense against cystinuria is a prescription diet aimed at lowering levels of cystine in the urine. Veterinarians also may prescribe medications to lower cystine. If blockages have already occurred, they may be able to be removed non-surgically. If not, surgery can remove the stones.

Symptoms

Signs that a dog may be suffering from cystinuria include difficulty and pain when urinating, like straining, blood in the urine, or only releasing small amounts of urine at a time. In untreated cases, cystinuria can lead to urinary tract infection, kidney infection, and even death.

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