Neonatal Cerebellar Cortical Degeneration

Body function:
Muscle & Neurological
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Neonatal cerebellar cortical degeneration (NCCD), also known as cerebellar abiotrophy, is a genetic neurological disorder affecting Beagle puppies. Dogs with this condition experience a progressive degeneration of the cerebellum, a part of the brain responsible for coordinating movement and balance.
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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Australian Kelpie

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What does this mean for a dog with this trait?

Currently, there is no cure for NCCD, and treatment primarily focuses on alleviating symptoms and improving quality of life. While the progression of the disorder is generally minimal, certain medications may be prescribed to help control symptoms and provide some relief.

Symptoms

The disorder manifests early in life, typically around three weeks of age, as the puppies begin to walk. NCCD presents with a range of motor and coordination difficulties. Affected puppies often display a lack of coordination and a broad-based stance, struggling to maintain balance. Their gait may appear unsteady, and they might exhibit tremors, especially as they try to perform voluntary movements. The condition also causes an uncoordinated or "toy soldier" type of leg movement and intention tremors, where shaking of the limbs or head intensifies as they approach a target.

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