Centronuclear Myopathy (Great Dane)

Body function:

Muscle & Neurological

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Centronuclear myopathy (CNM) is a muscular disease originally found in Great Danes. The disease occurs as a result of a mutation in the BIN1 gene and causes muscle weakness, exercise intolerance, and muscle wasting.

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List of affected breeds:

Genetic research has linked this gene and condition in the following breeds:

Great Dane

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What does this mean for a dog with this trait?

There is no known cure for centronuclear myopathy (Great Dane type). Depending on the severity of the condition, care may range from limiting exercise and offering plenty of breaks to compassionate euthanasia due to poor quality of life.

Symptoms

Centronuclear myopathy (Great Dane type) can occur in varying degrees of severity. Some dogs may experience some muscle weakness, but still tolerate a moderate amount of exercise, whereas others are unable to walk more than a few steps without collapse.

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