Spinocerebellar Ataxia (Parson Russell Terrier)

Spinocerebellar ataxia (SCA), or late-onset ataxia (LOA), is an inherited neurological disorder first identified in the Parson Russell Terrier. This condition results from a mutation in the CAPN1 gene. The disorder is characterized by a progressive loss of coordination and balance, typically beginning between six and twelve months of age. Affected dogs may experience worsening symptoms over time, and the disease often progresses to a point where euthanasia is considered due to severe impairment of mobility and overall quality of life.