Renal Cystadenocarcinoma and Nodular Dermatofibrosis
Body function: Reproductive & Urinary
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Renal cystadenocarcinoma and nodular dermatofibrosis (RCND) is a hereditary cancer syndrome affecting German Shepherd Dogs. The condition is characterized by the development of firm skin nodules (dermatofibrosis) and bilateral, multifocal tumors in the kidneys (cystadenocarcinoma). RCND manifests in a progressive and late-onset manner, typically emerging by around 6 years of age. The genetic mutation responsible for RCND has been identified as occurring in exon 7 of the folliculin (FLCN) gene. While animals with two copies of this mutation are not known to survive, those with one copy can develop the disease and may pass the mutation to their offspring.
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