Pyruvate Kinase Deficiency (Labrador)
Body function: Heart & Blood
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Pyruvate Kinase Deficiency (PKD) in Labrador Retrievers is a genetic metabolic disorder caused by a PKLR gene mutation. PKD results in insufficient activity of the pyruvate kinase enzyme. This deficiency affects red blood cells, making them easily damaged, leading to hemolytic anemia.
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