Pyruvate Kinase Deficiency (Beagle)
Body function: Heart & Blood
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Pyruvate Kinase Deficiency in Beagles is an inherited metabolic disorder caused by a mutation in the PKLR gene. To develop the condition, a dog must inherit one copy from each parent. PKD leads to insufficient activity in the pyruvate kinase enzyme, which is crucial for energy production in red blood cells. This deficiency causes premature destruction of red blood cells, leading to anemia and other complications.
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