Prekallikrein Deficiency

Prekallikrein Deficiency, also known as Fletcher factor deficiency or Fletcher trait, is a rare inherited blood disorder affecting Shih Tzus. It results from a mutation in the KLKB1 gene and must be inherited from both parents. Prekallikrein is a protein crucial in blood clotting, and its deficiency can cause excessive bleeding when blood does not clot. While many affected dogs may not show obvious symptoms, the condition can potentially cause severe bleeding complications, especially during surgery or trauma.