Persistent Müllerian Duct Syndrome
Body function: Muscle & Neurological
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Persistent müllerian duct syndrome (PMDS) is a reproductive disorder primarily affecting male dogs, characterized by the failure of the Müllerian ducts to regress during fetal development. This means that a male dog may have female reproductive organs. The condition is caused by a mutation in the AMHR2 gene and is inherited in a sex-limited autosomal recessive manner. While the genetic mutation has been documented in Miniature Schnauzers, it may also occur in other breeds, although the specific mutations in those breeds are not always identified. Female dogs are not affected by PMDS.
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