Neuronal Ceroid Lipofuscinosis 5
Body function: Muscle & Neurological
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Neuronal ceroid lipofuscinosis Type 5 (NCL-5) is a genetic lysosomal storage disease affecting Border Collies and other breeds, such as Australian Cattle Dogs and Golden Retrievers. It is caused by a mutation in the CLN5 gene, which is crucial for the normal function of lysosomal enzymes. This mutation leads to the accumulation of waste products within nerve cells, resulting in progressive neurological symptoms.
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