Narcolepsy (Doberman Pinscher)
Body function: Muscle & Neurological
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Narcolepsy in Doberman Pinschers is caused by an insertion mutation in HCRTR2 that causes one or more additional nucleotides to be inserted into the DNA sequence. This mutation is inherited as an autosomal recessive trait, meaning both parents must be carriers for the puppy to inherit the mutation. Puppies of just a single-parent carrier will also become carriers of the mutation. Doberman Pinschers with this form of narcolepsy will begin to show symptoms as early as 1 month and as late as 6 months of age.
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